Chlorhexidine-silver sulfadiazine-impregnated central venous catheters: in vitro antibacterial activity and impact on bacterial adhesion.
نویسندگان
چکیده
The aim of this study was to compare the in vitro activity and the impact on bacterial adhesion of two different catheters, one impregnated with chlorhexidine-silver sulfadiazine (C-SS) and the other not impregnated with antibacterial agents. The antimicrobial coating prevented the bacterial colonization by slime positive Staphylococcus epidermidis in the first two days. The antibacterial activity of the effluents from catheters impregnated with C-SS dissipated by day seven. Our results demonstrated that the surface treatment modified the composition of impregnated catheters and determined different contact angle values of the two catheters (impregnated and not impregnated). Examination of coated and uncoated catheter segments by scanning electron microscopy showed a good correlation with the results of adherence experiments. In conclusion, the findings suggest that C-SS coated catheters prevent in vitro bacterial adhesion.
منابع مشابه
Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis.
CONTEXT Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have recently been introduced for the prevention of catheter-related infections. However, there remains some uncertainty regarding the efficacy of these catheters because of conflicting reports in the literature. OBJECTIVE To evaluate the efficacy of chlorhexidine-silver sulfadiazine-impregnated central ve...
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CONTEXT A recent randomized controlled trial and meta-analysis indicated that central venous catheters impregnated with an antiseptic combination of chlorhexidine and silver sulfadiazine are efficacious in reducing the incidence of catheter-related bloodstream infection (CR-BSI); however, the ultimate clinical and economic consequences of their use have not been formally evaluated. OBJECTIVE ...
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متن کامل
ARROWgard Blue Clinical Bibliography EFFICACY OF ANTISEPTIC-IMPREGNATED CENTRAL VENOUS CATHETERS IN PREVENTING CATHETER-RELATED BLOODSTREAM INFECTION: A META-ANALYSIS
Considerable research has been conducted and published regarding the efficacy of ARROWgard Blue, chlorhexidine and silver sulfadiazine in suppressing microbial colonization, and their effect on reducing hospital costs. A catheter-related bloodstream infection can prolong hospitalization and substantually add to the cost of hospitalization. In addition, numerous studies have investigated the inc...
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عنوان ژورنال:
- The new microbiologica
دوره 35 2 شماره
صفحات -
تاریخ انتشار 2012